N-Carbethoxy-4-piperidone

Names

[ Name ]:
N-Carbethoxy-4-piperidone

[Synonym ]:
Ethyl 4-oxo-1-piperidinecarboxylate
N-carboethoxy-4-piperidinone
1-CARBETHOXY-4-PIPERIDONE
4-oxo-piperidine-1-carboxylic acid ethyl ester
EINECS 249-984-5
AURORA KA-3057
MFCD00006188
N-Ethoxycarbonyl-4-piperidinone
1-Ethoxycarbonyl-4-piperidinone
ethyl 4-oxopiperidine-1-carboxylate
N-ETHOXYCARBONYL-4-PIPERIDONE
N-Carbethoxy-4-piperidone
1-Carbethoxy-4-piperidone,1-Ethoxycarbonyl-4-piperidone,Ethyl 4-oxo-1-piperidinecarboxylate
1-(Ethoxycarbonyl)-4-piperidone
carbethoxy-4-piperidone
4-Oxo-1-piperidinecarboxylic acid ethyl ester
N-Carbethoxy-4-piperidon
Ethyl-4-oxopiperidin-1-carboxylat
1-carboethoxy-4-piperidone
1-Ethoxycarbonyl-4-oxopiperidine
Loratadine impurity H
N-CARBOETHOXY-4-PIPERIDONE
1-Piperidinecarboxylic acid, 4-oxo-, ethyl ester
1-Ethoxycarbonyl-4-piperidone
N-Carbithoxy-4-Piperidone
N-Carbethoxypiperidone
Loratadine Impurity 8

Biological Activity

[Description]:

N-Carbethoxy-4-piperidone is a metabolite of Loratadine (HY-17043). Loratadine is a selective inverse peripheral histamine H1-receptor agonist, and shows anti-dengue-virus (DENV) activity[1][2][3].

[In Vitro]

N-Carbethoxy-4-piperidone (piperidinone 4) shows toxicity to C. dubia, B. calyciflorus and P. subcapitata[1].

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
273.4±33.0 °C at 760 mmHg

[ Molecular Formula ]:
C₈H₁₃NO₃

[ Molecular Weight ]:
171.194

[ Flash Point ]:
87.8±0.0 °C

[ Exact Mass ]:
171.089539

[ PSA ]:
46.61000

[ LogP ]:
-0.31

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.483

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
slightly soluble

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/38

[ Safety Phrases ]:
S23-S24/25-S37/39-S26

[ WGK Germany ]:
3

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%