Didemethylclomipramine

[ Density]:
1.129g/cm3

[ Boiling Point ]:
439.5ºC at 760mmHg

[ Molecular Formula ]:
C₁₈H₂₂Cl₂N₂

[ Molecular Weight ]:
337.28700

[ Flash Point ]:
219.6ºC

[ Exact Mass ]:
336.11600

[ PSA ]:
15.27000

[ LogP ]:
5.44410

[ Index of Refraction ]:
1.583

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H332

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
20/21/22

[ Safety Phrases ]:
36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Click to get detail synthetic route

Precursor

DownStream

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Steady state concentrations of clomipramine and its major metabolite desmethylclomipramine in rat brain and serum after oral administration of clomipramine.

Eur. Neuropsychopharmacol. 10(5) , 401-5, (2000)

Twenty male Sprague-Dawley rats received five oral doses of clomipramine 20 mg/kg at 4-h intervals. The animals were decapitated 1, 2, 3, 5 and 12 h after the last dose for determination of clomiprami...

Clinical significance of plasma levels of clomipramine, its hydroxylated and desmethylated metabolites: prediction of clinical outcome in mood disorders using discriminant analysis of therapeutic drug monitoring data.

J. Affect. Disord. 29(4) , 267-79, (1993)

We measured the plasma concentrations of clomipramine and its metabolites, N-desmethylclompiramine, 8-hydroxy-N-desmethylclomipramine, 8-hydroxyclomipramine in 65 depressed patients with subtypes of D...

Pharmacokinetics of clomipramine in dogs following single-dose and repeated-dose oral administration.

Am. J. Vet. Res. 61(1) , 80-5, (2000)

To determine pharmacokinetics of clomipramine and its principle metabolite (desmethylclomipramine) in the plasma of dogs following single-dose and repeated-dose oral administration at various dosages....

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