Hydroxyphenyllactic acid

Names

[ CAS No. ]:
306-23-0

[ Name ]:
Hydroxyphenyllactic acid

[Synonym ]:
p-Hydroxyphenyl lactic acid
2-Hydroperoxy-2-phenylpropanoic acid
dl-p-Hydroxyphenyllactic acid
DL-4-Hydroxyphenyllactic Acid
3-(p-hydroxyphenyl)-D,L-lactic acid
4-Hydroxyphenyllactic acid
3-(4-hydroxyphenyl)-lactic acid
Benzeneacetic acid, α-hydroperoxy-α-methyl-
3-(4'-Hydroxyphenyl)-2-hydroxypropanoic acid
HPLA
2-Hydroxy-3-(p-hydroxyphenyl)propionic acid
2-hydroxy-3-(4-hydroxyphenyl)propanoic acid

Biological Activity

[Description]:

Hydroxyphenyllactic acid is an antifungal metabolite.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Fungal

Natural Products >> Acids and Aldehydes

Research Areas >> Infection

[Target]

Human Endogenous Metabolite

[In Vitro]

Hydroxyphenyllactic acid (4-hydroxyphenyllactic acid) is an antifungal metabolite[1].

[References]

[1]. Mu W, et al. Production of 4-hydroxyphenyllactic acid by Lactobacillus sp. SK007 fermentation. J Biosci Bioeng. 2010 Apr;109(4):369-71.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
370.0±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₀O₄

[ Molecular Weight ]:
182.173

[ Flash Point ]:
152.5±19.4 °C

[ Exact Mass ]:
182.057907

[ PSA ]:
77.76000

[ LogP ]:
2.13

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.563

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OD5500000

CHEMICAL NAME :: Lactic acid, 3-(p-hydroxyphenyl)-

CAS REGISTRY NUMBER :: 306-23-0

LAST UPDATED :: 199803

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C9-H10-O4

MOLECULAR WEIGHT :: 182.19

WISWESSER LINE NOTATION :: QVY1&OR DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg female 15-21 day(s) after conception

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis Lungs, Thorax, or Respiration - tumors

REFERENCE :: BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956- Volume(issue)/page/year: 87,46,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg female 15-21 day(s) after conception

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis Blood - tumors

REFERENCE :: BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956- Volume(issue)/page/year: 87,46,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors

REFERENCE :: VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 22(6),47,1976

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2800 mg/kg/10W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Blood - leukemia

REFERENCE :: GETRE8 Gematologiya i Transfuziologiya. Hematology and Transfusion Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.28- 1983- Volume(issue)/page/year: 28(2),50,1983

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ HS Code ]:
2918290000

Customs

[ HS Code ]: 2918290000

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%