CPYPP

Names

[ Name ]:
CPYPP

[Synonym ]:
(4Z)-4-[(2E)-3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione
3,5-Pyrazolidinedione, 4-[(2E)-3-(2-chlorophenyl)-2-propen-1-ylidene]-1-phenyl-, (4Z)-

Biological Activity

[Description]:

CPYPP is a small-molecule inhibitor of the Rac activator DOCK2 with IC50 of 22.8 uM (DOCK2DHR-2-mediated Rac GEF activity), inhibits DOCK2-Rac1 interaction; binds to DOCK2 DHR-2 domain in a reversible manner and inhibited its catalytic activity in vitro; blocks both chemokine receptor- and antigen receptor-mediated Rac activation in lymphocytes, resulting in marked reduction of chemotactic response and T cell activation.

[References]

References 1. Nishikimi A, et al. Chem Biol. 2012 Apr 20;19(4):488-97. 2. Watanabe M, et al. J Immunol. 2014 Dec 1;193(11):5660-7. View Related Products by Target Small GTPase

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₁₈H₁₃ClN₂O₂

[ Molecular Weight ]:
324.761

[ Exact Mass ]:
324.066559

[ LogP ]:
3.35

[ Index of Refraction ]:
1.728

Safety Information

[ Hazard Codes ]:
Xi