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Triiodothyronine sulfate

Names

[ CAS No. ]:
31135-55-4

[ Name ]:
Triiodothyronine sulfate

[Synonym ]:
(2S)-2-amino-3-[3,5-diiodo-4-(3-iodo-4-sulfooxyphenoxy)phenyl]propanoic acid
Liothyronine Sulfate
T3 Sulfate
Triiodothyronine sulfic acid
triiodothyronine sulfate
Triiodothyronine sulfuric ester
3,5-diiodo-O-[3-iodo-4-(sulfooxy)phenyl]-L-tyrosine

Biological Activity

[Description]:

Triiodothyronine sulfate is the main metabolite of thyroid hormone triiodothyronine (T3). Triiodothyronine is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

Triiodothyronine (T3, 100 nM) stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed[2]. Liothyronine binds to human β1 thyroid hormone receptor (hTRβ1), and change its conformation. Triiodothyronine promotes growth, induces differentiation and regualtes metabolic effects[3].

[References]

[1]. J S LoPresti, et al. 3,5,3'-Triiodothyronine (T3) sulfate: a major metabolite in T3 metabolism in man. J Clin Endocrinol Metab. 1994 Mar;78(3):688-92.

[2]. Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94.

[3]. Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H12I3NO7S

[ Molecular Weight ]:
731.04

[ Exact Mass ]:
730.74700

[ PSA ]:
144.53000

[ LogP ]:
5.20980

Related Compounds