4-(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)butanoic acid

Names

[ Name ]:
4-(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)butanoic acid

[Synonym ]:
MFCD00196079
4-(1,3-dioxoisoindol-2-yl)butanoic acid
4-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BUTANOIC ACID
2H-Isoindole-2-butanoic acid, 1,3-dihydro-1,3-dioxo-
4-Phthalimidobutyric Acid

Biological Activity

[Description]:

4-(N-Phthalimidoyl)butanoic acid (compound FB) is a hapten with a carboxyl group at the end of its spacer arm, suitable for reacting with free amine groups of proteins. 4-(N-Phthalimidoyl)butanoic acid can be combined with carrier proteins and used in antigen design[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[References]

[1]. Mercader JV, et al. Development of monoclonal ELISAs for azinphos-methyl. 1. Hapten synthesis and antibody production. J Agric Food Chem. 1999 Mar;47(3):1276-84.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
442.1±28.0 °C at 760 mmHg

[ Melting Point ]:
119-121ºC

[ Molecular Formula ]:
C₁₂H₁₁NO₄

[ Molecular Weight ]:
233.220

[ Flash Point ]:
221.2±24.0 °C

[ Exact Mass ]:
233.068802

[ PSA ]:
74.68000

[ LogP ]:
1.58

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.605

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NR3459000

CHEMICAL NAME :: 2-Isoindolinebutyric acid, 1,3-dioxo-

CAS REGISTRY NUMBER :: 3130-75-4

BEILSTEIN REFERENCE NO. :: 0208243

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H11-N-O4

MOLECULAR WEIGHT :: 233.24

WISWESSER LINE NOTATION :: T56 BVNVJ C3VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 327 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 27,805,1989 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 400 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 28,680,1973

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ HS Code ]:
2925190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%