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CMPD167

Names

[ CAS No. ]:
313994-79-5

[ Name ]:
CMPD167

[Synonym ]:
N-[(1R,3S,4S)-3-{[4-(3-Benzyl-1-ethyl-1H-pyrazol-5-yl)-1-piperidinyl]methyl}-4-(3-fluorophenyl)cyclopentyl]-N-methyl-D-valine
D-Valine, N-[(1R,3S,4S)-3-[[4-[1-ethyl-3-(phenylmethyl)-1H-pyrazol-5-yl]-1-piperidinyl]methyl]-4-(3-fluorophenyl)cyclopentyl]-N-methyl-
MRK-1

Biological Activity

[Description]:

CMPD167 (MRK-1) is an orally acitve small molecule that binds to CCR5 to inhibit gp120 association, inhibits different stages of the virus-cell attachment and entry process (CCR5-using virus SHIV-162P3, IC50<1 nM).

[References]

References 1. Veazey RS, et al. Nature. 2005 Nov 3;438(7064):99-102. 2. Veazey RS, et al. Nat Med. 2005 Dec;11(12):1293-4. 3. Ketas TJ, et al. Virology. 2007 Aug 1;364(2):431-40. 4. Malcolm RK, et al. Antimicrob Agents Chemother. 2012 May;56(5):2251-8. View Related Products by Target Chemokine Receptor (CCR and CXCR)

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
694.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C35H47FN4O2

[ Molecular Weight ]:
574.772

[ Flash Point ]:
373.8±31.5 °C

[ Exact Mass ]:
574.368286

[ LogP ]:
6.27

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.607

Related Compounds