Kavain
Names
[ CAS No. ]:
3155-48-4
[ Name ]:
Kavain
[Synonym ]:
DL-Kawain
2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-[(E)-2-phenylethenyl]-
4-Methoxy-6-[(E)-2-phenylvinyl]-5,6-dihydro-2H-pyran-2-one
trans-5,6-Dihydro-4-methoxy-6-(2-phenylethenyl)-2H-pyran-2-one,DL-Kawain
KAVAIN,DL
UNII:5L1NI60TGB
Kawain,DL
Kawain
Kavain
2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-(2-phenylethenyl)-, (E)-(±)-
MFCD00270446
Kawain, DL-
2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-styryl-
Kavain, dl-
DL-KAVAIN
Biological Activity
[Description]:
[In Vitro]
[References]
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
432.6±45.0 °C at 760 mmHg
[ Melting Point ]:
142-148ºC
[ Molecular Formula ]:
C14H14O3
[ Molecular Weight ]:
230.259
[ Flash Point ]:
184.6±23.3 °C
[ Exact Mass ]:
230.094299
[ PSA ]:
35.53000
[ LogP ]:
1.69
[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C
[ Index of Refraction ]:
1.565
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R22
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
Articles
Forensic Sci. Int. 249 , e7-11, (2015)
Kavalactones are a group of compounds found in kava, a beverage or extract prepared from the rhizome of the kava plant (Piper methysticum). Traditionally kava extracts have been used for their anxioly...
Kavalactones fail to inhibit alcohol dehydrogenase in vitro.Phytomedicine 13(3) , 192-5, (2006)
In recent years, Kava kava (Piper methysticum, Forst. f., Piperaceae), a folkloric beverage and popular herbal remedy, has been implicated in a number of liver failure cases. Many hypotheses as to the...
Kavalactones Yangonin and Methysticin induce apoptosis in human hepatocytes (HepG2) in vitro.Phytother Res. 25(3) , 417-23, (2011)
While cases of severe kava hepatotoxicity have been reported, studies examining the toxicity of individual kavalactones are limited. The present study examined the in vitro hepatotoxicity of kavain, m...