(Trimethylsilyl)methanol

Names

[ Name ]:
(Trimethylsilyl)methanol

[Synonym ]:
(Trimethylsilyl)methanol
1-TRIMETHYLSILYLMETHANOL
Trimethylhydroxymethylsilane
TriMethylsilylMethanol
Methanol, 1-(trimethylsilyl)-
methoxytrimethylsilane
EINECS 221-746-5
trimethylsilanyl-methanol
Hydroxymethyltrimethylsilane
(Hydroxymethyl)trimethylsilane
MFCD00004596

Chemical & Physical Properties

[ Density]:
0.8±0.1 g/cm3

[ Boiling Point ]:
119.8±13.0 °C at 760 mmHg

[ Melting Point ]:
<0ºC

[ Molecular Formula ]:
C₄H₁₂OSi

[ Molecular Weight ]:
104.223

[ Flash Point ]:
31.1±0.0 °C

[ Exact Mass ]:
104.065742

[ PSA ]:
20.23000

[ LogP ]:
0.83

[ Vapour Pressure ]:
7.6±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.398

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PC4100000

CHEMICAL NAME :: Methanol, (trimethylsilyl)-

CAS REGISTRY NUMBER :: 3219-63-4

BEILSTEIN REFERENCE NO. :: 1731486

LAST UPDATED :: 199712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C4-H12-O-Si

MOLECULAR WEIGHT :: 104.25

WISWESSER LINE NOTATION :: Q1-SI-1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1080 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DANKAS Doklady Akademii Nauk SSSR. Proceedings of the Academy of Sciences of the USSR. For English translation, see DBIOAM and DKBSAS. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1933- Volume(issue)/page/year: 229,1011,1976

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R10

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
UN 1987 3/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
PC4100000

[ Packaging Group ]:
III

[ Hazard Class ]:
3

[ HS Code ]:
2931900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2931900090

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

Articles

Enantioselective esterification of racemic naproxen by lipases in organic solvent.

Enzyme Microb. Technol. 16(4) , 328-33, (1994)

Enantioselective esterification of naproxen, 2-(6-methoxy-2-naphthyl) propionic acid, was attempted by lipases in nearly anhydrous isooctane. The nature of the alcohol affects the reactivity and enant...

Efficient kinetic resolution of (R,S)-1-trimethylsilylethanol via lipase-mediated enantioselective acylation in ionic liquids.

Chirality 18(10) , 814-21, (2006)

Efficient enantioselective acylation of (R,S)-1-trimethylsilylethanol {(R,S)-1-TMSE} with vinyl acetate catalyzed by immobilized lipase from Candida antarctica B (i.e., Novozym 435) was successfully c...

E. Vedejs, G.R. Martinez

J. Am. Chem. Soc. 101 , 6452, (1979)