3-Phenyltoxoflavin

Names

[ Name ]:
3-Phenyltoxoflavin

[Synonym ]:
3-Phenyl-toxoflavin

Biological Activity

[Description]:

3-Phenyltoxoflavin, a derivative of Toxoflavin, is an Hsp90 inhibitor, with a Kd of 585 nM for the interaction of Hsp90-TPR2A. 3-Phenyltoxoflavin has anti-cancer activity[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> HSP

Signaling Pathways >> Cell Cycle/DNA Damage >> HSP

[Target]

HSP90:585 nM (Kd)

[In Vitro]

3-Phenyltoxoflavin (1 nM-100 μM; 4 d) inhibits BT474 cells proliferation in a concentration-dependent manner, with an IC50 of 690 nM[1]. 3-Phenyltoxoflavin (0.56 nM-100 μM; 2 h) competes with biotinylated Hsp90 peptide for its binding to TPR2A in a dose-dependent manner[1].

[References]

[1]. Yi F, et, al. A novel class of small molecule inhibitors of Hsp90. ACS Chem Biol. 2008 Oct 17;3(10):645-54.

[2]. Koh S, et, al. A novel light-dependent selection marker system in plants. Plant Biotechnol J. 2011 Apr;9(3):348-58.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₁N₅O₂

[ Molecular Weight ]:
269.25900

[ Exact Mass ]:
269.09100

[ PSA ]:
82.67000

[ LogP ]:
0.08920

Safety Information

[ Hazard Codes ]:
Xi

3-Phenyltoxoflavin

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds