5-Bromo-2-chloropyrimidine

Names

[ Name ]:
5-Bromo-2-chloropyrimidine

[Synonym ]:
T6N CNJ BG EE
5-BROMO-2-CHLOROPYRIMIDNE
Pyrimidine, 5-bromo-2-chloro-
2-chloro-5-bromopyrimidine(5-bromo-2-chloropyrimidine)
2C5BP
MAJORIMPURITYIS2,5-DIBROMOPYRIMIDINE
PYRIMIDINE,5-BROMO-2-CHLORO
5-bromo-2-chloro-pyrimidine
MFCD00483232
2-CHLORO-5-BROMOPYRIMIDINE
5-Bromo-2-chloropyrimidine
5-Bromo-2-chloro-1,3-diazine
2,5-bromochloro pyrimidine
2-chloro-5-bromopyridine

Biological Activity

[Description]:

5-Bromo-2-chloropyrimidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

[In Vitro]

用作医药中间体，用于合成抑制剂等医药品。它还用于铟有机金属化合物与 2,5-二卤嘧啶的交叉偶联反应。

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
291.6±13.0 °C at 760 mmHg

[ Melting Point ]:
76-81 °C(lit.)

[ Molecular Formula ]:
C₄H₂BrClN₂

[ Molecular Weight ]:
193.43

[ Flash Point ]:
130.1±19.8 °C

[ Exact Mass ]:
191.908981

[ PSA ]:
25.78000

[ LogP ]:
1.36

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.588

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/39-S37/39

[ RIDADR ]:
UN 3335

[ WGK Germany ]:
3

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Cross-coupling reactions of indium organometallics with 2,5-dihalopyrimidines: synthesis of hyrtinadine A.

Org. Lett. 10(17) , 3745-8, (2008)

The palladium-catalyzed cross-coupling reaction of triorganoindium reagents (R3In) with 5-bromo-2-chloropyrimidine proceeds chemoselectively, in good yields, to give 5-substituted-2-chloropyrimidines ...

Improved synthesis of 2,2'-bipyrimidine.

J. Org. Chem. 67(18) , 6550-2, (2002)

A high-yield synthesis was developed for the preparation of 2,2'-bipyrimidine (1) using the Ullmann coupling of 2-iodopyrimidine. The new procedure was also used for the preparation of 4,4',6,6'-tetra...