validamine

Names

[ Name ]:
validamine

[Synonym ]:
PT 141
Pt141 Acetate
(1R,2S,3S,4S,6R)-4-Amino-6-(hydroxymethyl)-1,2,3-cyclohexanetriol
1s-(1,2,4/3,5)-1-amino-5-hydroxymethyl-2,3,4-cyclohexantriol
1,2,3-Cyclohexanetriol, 4-amino-6-(hydroxymethyl)-, (1R,2S,3S,4S,6R)-
MFCD08063357
(1R,2S,3S,4S,6R)-4-Amino-6-(hydroxymethyl)cyclohexane-1,2,3-triol
Bremelanotide Acetate
Validamine
1-Amino-5-(hydroxymethyl)-1,5,6-trideoxy-D-chiro-inositol
(1R,2S,3S,4S)-4-amino-6-(hydroxymethyl)cyclohexane-1,2,3-triol
PT-141 (BREMELANOTIDE)
Bremelanotide,PT141,Acetate
1-Amino-1,5,6-trideoxy-5-(hydroxymethyl)-D-chiro-inositol

Biological Activity

[Description]:

Validamine competitively inhibits β-glucosidase in a pH-dependent and dose-dependent manner, with an IC50 value of 2.92mM, and the maximum inhibitory ability is at the optimum pH value of this enzyme[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[Target]

IC50 value of 2.92mM[1]

[References]

[1]. Takeuchi M, et al. Inhibitory effect of validamine, valienamine and valiolamine on activities of carbohydrases in rat small intestinal brush border membranes. Chem Pharm Bull (Tokyo). 1990 Jul;38(7):1970-2.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
345.6±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C₇H₁₅NO₄

[ Molecular Weight ]:
177.20

[ Flash Point ]:
162.8±27.9 °C

[ Exact Mass ]:
177.100113

[ PSA ]:
106.94000

[ LogP ]:
-2.36

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.599

Safety Information

[ HS Code ]:
2922199090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%