InS3-54

An STAT3 inhibitor that selectively targets the DNA-binding domain of STAT3, without affecting the activation and dimerization of STAT3; preferentially suppresses proliferation of cancer over non-cancer cells and inhibits migration and invasion of malignant cells; selectively inhibits STAT3 binding to DNA without affecting the activation and dimerization of STAT3; inhibits expression of STAT3 downstream target genes and STAT3 binding to chromatin in situ.

References 1. Huang W, et al. ACS Chem Biol. 2014 May 16;9(5):1188-96. 2. Huang W, et al. Oncogene. 2016 Feb 11;35(6):783-92. View Related Products by Target STAT