3,5-Dichloro-4-hydroxybenzoic acid

Names

[ Name ]:
3,5-Dichloro-4-hydroxybenzoic acid

[Synonym ]:
4-hydroxy-3,5-dichloro-benzoic acid
BENZOIC ACID,3,5-DICHLORO-4-HYDROXY
acide dichloro-3,5 hydroxy-4 benzoique
DiClHBz
3,5-Dichloro-4-hydroxybenzoic acid
EINECS 222-071-9
3,5-dichloro-4-hydroxy-benzoic acid
Benzoic acid, 3,5-dichloro-4-hydroxy-
3,5-Dichloro-4-hydroxybenzoicAcid
3,5-Dichlor-4-hydroxy-benzoesaeure
MFCD00002550

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
328.2±42.0 °C at 760 mmHg

[ Melting Point ]:
264-266 °C(lit.)

[ Molecular Formula ]:
C₇H₄Cl₂O₃

[ Molecular Weight ]:
207.011

[ Flash Point ]:
152.3±27.9 °C

[ Exact Mass ]:
205.953751

[ PSA ]:
57.53000

[ LogP ]:
3.37

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.641

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG7502000

CHEMICAL NAME :: Benzoic acid, 3,5-dichloro-4-hydroxy-

CAS REGISTRY NUMBER :: 3336-41-2

BEILSTEIN REFERENCE NO. :: 2616297

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H4-Cl2-O3

MOLECULAR WEIGHT :: 207.01

WISWESSER LINE NOTATION :: QVR DQ CG EG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex)

REFERENCE :: JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 2,213,1960

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DG7502000

[ HS Code ]:
2918290000

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918290000

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

Articles

Study of Cytotoxic Effects of Benzonitrile Pesticides.

Biomed Res. Int. 2015 , 381264, (2015)

The benzonitrile herbicides bromoxynil, chloroxynil, dichlobenil, and ioxynil have been used actively worldwide to control weeds in agriculture since 1970s. Even though dichlobenil is prohibited in EU...

Potent human uric acid transporter 1 inhibitors: in vitro and in vivo metabolism and pharmacokinetic studies.

Drug Des. Devel. Ther. 6 , 323-39, (2012)

Human uric acid transporter 1 (hURAT1; SLC22A12) is a very important urate anion exchanger. Elevated urate levels are known to play a pivotal role in cardiovascular diseases, chronic renal disease, di...

Preparation and Characterization of a Polyclonal Antibody against Brominated Protein.

J. Clin. Biochem. Nutr. 44 , 95-103, (2009)

(Di)bromotyrosine is formed by the specific reaction of eosinophil peroxidase and can be used as an eosinophil activation marker. In the present study, an antibody for (di)bromotyrosine in proteins wa...