Citicoline sodium salt

Names

[ Name ]:
Citicoline sodium salt

[Synonym ]:
Cytidine, 5'-O-[hydroxy[[hydroxy[2-(trimethylammonio)ethoxy]phosphinyl]oxy]phosphinyl]-, inner salt, sodium salt (1:1)
EINECS 251-689-1
Neuroton
CITICOLINE SODIUM SALT
MFCD00150508
Cytidine 5‘-diphosphocholine sodium salt hydrate
Choline Hydroxide 5'-Ester with Cytidine 5'-(Sodium Dihydrogen Diphosphate) Inner Salt
CDP-choline-Na
Citicoline Sodium
Cytidine 5'-(Trihydrogen Diphosphate) P'-(2-(Trimethylammonio)ethyl) Ester Inner Salt Monosodium Salt
Cytidine 5′-diphosphocholine sodium salt
Sodium 5'-O-[({[2-(trimethylammonio)ethoxy]phosphinato}oxy)phosphinato]cytidine
Citicoline sodium salt hydrate
Cidifos
Cytidine 5'-(Trihydrogen Diphosphate) Mono(2-(trimethylammonio)ethyl) Ester Hydroxide Inner Salt Monosodium Salt

Biological Activity

[Description]:

Cytidoline sodium salt is an intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes and also exerts neuroprotective effects.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Davinelli S, et al. Cytoprotective Effects of Citicoline and Homotaurine against Glutamate and High Glucose Neurotoxicity in Primary Cultured Retinal Cells. Oxid Med Cell Longev. 2017;2017:2825703.

[2]. Karpova MN, et al. Increase of the seizure threshold in C57BL/6 mice after citicoline administration. Bull Exp Biol Med. 2015 Jan;158(3):315-7.

[Related Small Molecules]

Chemical & Physical Properties

[ Melting Point ]:
259-268°C (dec.)

[ Molecular Formula ]:
C₁₄H₂₆N₄NaO₁₁P₂

[ Molecular Weight ]:
511.31

[ PSA ]:
238.17000

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivo.

Br. J. Cancer 111(2) , 318-25, (2014)

The modest benefits of gemcitabine (dFdC) therapy in patients with pancreatic ductal adenocarcinoma (PDAC) are well documented, with drug delivery and metabolic lability cited as important contributin...

A randomized dose-response trial of citicoline in acute ischemic stroke patients. Citicoline Stroke Study Group.

Neurology 49 , 671-678, (1997)

Citicoline (CDP-choline) is a key intermediary in the biosynthesis of phosphatidylcholine, an important component of the neural cell membrane. It has been shown to produce beneficial effects in both a...

Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats.

Stroke 28 , 1060-1065, (1997)

Citicoline, a naturally occurring precursor of phosphatidylcholine, is neuroprotective and is currently being assessed in clinical trials. To evaluate potential synergistic neuroprotective effects of ...