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VPC-18005

Names

[ CAS No. ]:
339304-10-8

[ Name ]:
VPC-18005

[Synonym ]:
{2-[(2E)-2-(4-Isopropylbenzylidene)hydrazino]-4-oxo-4,5-dihydro-1,3-thiazol-5-yl}acetic acid
2-(2-{(Z)-2-[(E)-(4-isopropylphenyl)methylidene]hydrazono}-4-oxo-1,3-thiazolan-5-yl)acetic acid
5-Thiazoleacetic acid, 4,5-dihydro-2-[(2E)-2-[[4-(1-methylethyl)phenyl]methylene]hydrazinyl]-4-oxo-
MFCD00758307
MFCD28248832

Biological Activity

[Description]:

VPC-18005 (VPC18005) is a novel small molecule ERG (ETS-related gene) antagonist that inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, disrupts the ERG binding to DNA (Kd=250 uM); markedly decreases SOX9 expression, inhibits migration and invasion of ERG-overexpressing prostate cancer cells in vitro, and reduces metastasis in a zebrafish xenograft model.

[References]

References 1. Butler MS, et al. Oncotarget. 2017 Jun 27;8(26):42438-42454. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
506.3±52.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H17N3O3S

[ Molecular Weight ]:
319.379

[ Flash Point ]:
260.0±30.7 °C

[ Exact Mass ]:
319.099060

[ LogP ]:
2.72

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.647

Related Compounds