Ornipressin

Names

[ Name ]:
Ornipressin

[Synonym ]:
Glycinamide, 1-[[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentaazacycloeicos-4-yl]carbonyl]-L-prolyl-L-ornithyl-
POR-8
8-Ornithinevasopressin
8-L-Ornithinevasopressin
8-L-Ornithine-vasopressin
EINECS 222-253-8
8-ornipressin vasopressin
Ornithine-vasopressin
vasopressin 8-ornithine
POR-8 Sandoz
Orn8-vasopressin
1-{[(4R,7S,10S,13S,16S,19R)-19-Amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-L-ornithylglycinamide
Ornipressin Acetate

Biological Activity

[Description]:

Ornipressin is a potent vasoconstrictor, hemostatic and renal agent. Sequence: Cys-Tyr-Phe-Gln-Asn-Cys-Pro-{Orn}-Gly-NH2 (Disulfide bridge: Cys1-Cys6).

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Cardiovascular Disease

Peptides

[References]

[1]. Fruhstorfer H, et al. Dose-response relation of ornipressin with regard to vasoconstriction in human skin. Br J Anaesth. 1994 Aug;73(2):220-4.

[2]. De Kock M, et al. Ornipressin (Por 8): An efficient alternative to counteract hypotension during combined general/epidural anesthesia. Anesth Analg. 2000 Jun;90(6):1301-7.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
1616.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₅H₆₃N₁₃O₁₂S₂

[ Molecular Weight ]:
1042.192

[ Flash Point ]:
931.3±34.3 °C

[ Exact Mass ]:
1041.416016

[ PSA ]:
476.15000

[ LogP ]:
-5.66

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.583

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Codes ]:
F,Xi,N

[ Risk Phrases ]:
R11:Highly Flammable. R36/37/38:Irritating to eyes, respiratory system and skin . R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . R10:Flammable.

[ Safety Phrases ]:
S16-S26-S60-S37/39

[ RIDADR ]:
UN 1126 3/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
EJ6225000

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
29033036

Customs

[ HS Code ]: 29033036