4,4′-difluorobenzophenone

Names

[ CAS No. ]:
345-92-6

[ Name ]:
4,4′-difluorobenzophenone

[Synonym ]:
p,p'-Difluorobenzophenone
Di-p-fluorophenyl ketone
Methanone, bis(4-fluorophenyl)-
4,4‘-Difluorobenzophenone
Bis(4-fluorophenyl)methanone
EINECS 206-466-3
4-fluorophenyl ketone
Bis(4-Fluorophenyl)-Methanone
4.4'-difluorobenzophenone
4,4'-Difluorobenzophenone
p-Fluorophenyl ketone
4,4′-difluorobenzophenone
di(4-fluorophenyl)methanone
MFCD00000353

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
308.8±27.0 °C at 760 mmHg

[ Melting Point ]:
102-105 °C(lit.)

[ Molecular Formula ]:
C₁₃H₈F₂O

[ Molecular Weight ]:
218.199

[ Flash Point ]:
118.4±17.9 °C

[ Exact Mass ]:
218.054321

[ PSA ]:
17.07000

[ LogP ]:
3.62

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.550

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ0685000

CHEMICAL NAME :: Benzophenone, 4,4'-difluoro-

CAS REGISTRY NUMBER :: 345-92-6

BEILSTEIN REFERENCE NO. :: 0516231

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C13-H8-F2-O

MOLECULAR WEIGHT :: 218.21

WISWESSER LINE NOTATION :: FR DVR DF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04689

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335-H411

[ Precautionary Statements ]:
P261-P273-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
UN 3077 9 / PGIII

[ WGK Germany ]:
3

[ RTECS ]:
DJ0685000

[ Packaging Group ]:
I; II; III

[ HS Code ]:
2914700090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Articles

Oxidative metabolism of flunarizine in rat liver microsomes.

Res. Commun. Chem. Pathol. Pharmacol. 78(1) , 85-95, (1992)

The oxidative metabolism of flunarizine [1-[bis(4-fluorophenyl)-methyl]-4-(3-phenyl-2-propenyl)piperazine, FZ] to 1-[bis-(4-fluorophenyl)methyl]piperazine (M-1), 1-[bis(4-fluorophenyl)methyl]-4-[3-(4'...

Poly (aryl ether ketone) s with carboxylic acid groups: synthesis, sulfonation and crosslinking. Liu B, et al.

J. Mater. Chem. 18(39) , 4675-4682, (2008)