3-Methoxy-5-(trifluoromethyl)aniline

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
242.0±40.0 °C at 760 mmHg

[ Melting Point ]:
50-52 °C(lit.)

[ Molecular Formula ]:
C₈H₈F₃NO

[ Molecular Weight ]:
191.150

[ Flash Point ]:
100.2±27.3 °C

[ Exact Mass ]:
191.055801

[ PSA ]:
35.25000

[ LogP ]:
2.78

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.477

Click to get detail MSDS

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H315-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
PG3

[ WGK Germany ]:
3

[ HS Code ]:
2922299090

Precursor

DownStream

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK).

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A series of SYK inhibitors based on the phenylamino pyrimidine thiazole lead 4 were prepared and evaluated for biological activity. Lead optimization provided compounds with nanomolar K(i)'s against S...

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