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Phox-I2

Names

[ CAS No. ]:
353495-22-4

[ Name ]:
Phox-I2

Biological Activity

[Description]:

Phox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binds to p67phox with high affinity with a Kd of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

Kd: 150 nM (p67phox)[1]


[In Vitro]

Phox-I2 可有效抑制 dHL-60 细胞和原代人中性粒细胞中 NOX2 介导的超氧化物产生，并具有剂量依赖性，且没有可检测到的细胞毒性[1]。

[References]

[1]. Emily E Bosco, et al. Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation. Chem Biol. 2012 Feb 24;19(2):228-42.  

Chemical & Physical Properties

[ Molecular Formula ]:
C18H15N3O4

[ Molecular Weight ]:
337.33

[ Exact Mass ]:
337.10600

[ PSA ]:
103.67000

[ LogP ]:
5.51390

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H335

[ Precautionary Statements ]:
P261

[ RIDADR ]:
NONH for all modes of transport

Related Compounds