HBED dihydrochloride

Names

[ Name ]:
HBED dihydrochloride

[Synonym ]:
hbed 2hcl 2h2o

Biological Activity

[Description]:

HBED dihydrochloride is an orally active and hexadentate phenolic aminocarboxylate iron chelator. HBED refers to N, N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid, inducing iron excretion in primates. HBED dihydrochloride has the potential to be used as an alternative to desferriamine for iron chelation therapy[1].

[Related Catalog]:

Research Areas >> Others

[In Vivo]

HBED monohydrochloride dihydrate 在不同的给药方式下，产生的活性不同。HBED 以 81、162 和 324 μMol/kg 的剂量，口服给药后不会产生显著效果。而以 162 和 324 μMol/kg 的剂量，在皮下给药后，提高了净铁排泄量[1]。

[References]

[1]. Bergeron RJ, et al. HBED: the continuing development of a potential alternative to deferoxamine for iron-chelating therapy. Blood. 1999 Jan 1;93(1):370-5.

Chemical & Physical Properties

[ Melting Point ]:
130-134ºC

[ Molecular Formula ]:
C₂₀H₂₆Cl₂N₂O₆

[ Molecular Weight ]:
461.34

[ Exact Mass ]:
388.16300

[ PSA ]:
121.54000

[ LogP ]:
1.57120

MSDS

Click to get detail MSDS

Safety Information

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36/37/39