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β-Hederin

Names

[ CAS No. ]:
35790-95-5

[ Name ]:
β-Hederin

[Synonym ]:
Olean-12-en-28-oic acid, 3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-, (3β)-
(3β)-3-{[2-O-(6-Deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy}olean-12-en-28-oic acid

Biological Activity

[Description]:

β-Hederin, a saponin isolated from Hedera helix L.(Araliaceae), possesses antileishmanial activity. β-Hederin exhibits IC50 values of 1.5 μM, 68 nM and 4.57 μM in L. Mexicana promastigotes, L. mexicana amastigotes and THP1 cells, respectively[1][2].

[Related Catalog]:

Research Areas >> Infection
Research Areas >> Inflammation/Immunology

[References]

[1]. F Delmas, et al. Antileishmanial activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A1, as compared to their action on mammalian cells cultured in vitro. Planta Med. 2000 May;66(4):343-7.

[2]. O Ridoux, et al. In vitro antileishmanial activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A(1), in association with pentamidine and amphotericin B. Phytother Res. 2001 Jun;15(4):298-301.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
817.8±65.0 °C at 760 mmHg

[ Melting Point ]:
221-223ºC

[ Molecular Formula ]:
C41H66O11

[ Molecular Weight ]:
734.956

[ Flash Point ]:
240.5±27.8 °C

[ Exact Mass ]:
734.460510

[ PSA ]:
175.37000

[ LogP ]:
9.96

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.592

Precursor & DownStream

Precursor

DownStream

Related Compounds