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Uracil-13C

Names

[ CAS No. ]:
35803-45-3

[ Name ]:
Uracil-13C

[Synonym ]:
Uracil-2-13C
Uracil (2-13C) (JAN)
2-[(13)C]uracil
MFCD00084096

Biological Activity

[Description]:

Uracil-13C is the 13C labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2].

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Pałasz A, et al. In search of uracil derivatives as bioactive agents. Uracils and fused uracils: Synthesis, biological activity and applications. Eur J Med Chem. 2015 Jun 5;97:582-611.  

Chemical & Physical Properties

[ Density]:
1.322g/cm3

[ Melting Point ]:
>300ºC (dec.)(lit.)

[ Molecular Formula ]:
C4H4N2O2

[ Molecular Weight ]:
113.07900

[ Exact Mass ]:
113.03100

[ PSA ]:
65.72000

[ Index of Refraction ]:
1.502

MSDS

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Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds