3'-sialyllactose

Names

[ Name ]:
3'-sialyllactose

[Synonym ]:
N-acetylneuraminoyllactose
3'-Sialyllactose
3'-sialyllactose
3'-Sialyllactose (3'-SL)
32-N-Acetyl-a-neuraminyllactose
3'-N-Acetylneuraminyl-D-lactose
3'-Monosialyllactose
3'-a-Sialyllactose
N-acetylneuraminosyl-D-lactose
3'-Sialyl-D-lactose
a2,3-Sialyllactose

Biological Activity

[Description]:

3'-Sialyllactose (3'-SL) is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose can be used for the research of inflammation[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[In Vitro]

3'-Sialyllactose (0-250 μM; 24-36 h) promotes and restores Col2a1 synthesis and accumulates extracellular sulphated proteoglycan, and inhibits the effect of inflammatory cytokines[1]. 3'-Sialyllactose (0-250 μM; 24 h) activates the expression of Sox9 and inhibits NF-κB activation in chondrocytes[1]. Western Blot Analysis[1] Cell Line: Chondrocytes Concentration: 0, 50, 100 and 250 μM Incubation Time: 24-36 hours Result: Dose-dependently increased Col2a1 transcript and protein levels, and restored Col2a1 expression in IL-1β-treated chondrocytes. Dose-dependently inhibited IL-1β-induced Mmp3,Mmp13 and Cox2 expression in chondrocytes. Reduced expression of Mmp3, Mmp13 and Cox2 induced by IL-6, IL-17 and TNF-α in chondrocytes.

[In Vivo]

3'-Sialyllactose (10-100 mg/kg; p.o. three times a week for 6 weeks) protects mice against cartilage destruction from osteoarthritis[1]. Animal Model: 8-week-old male C57BL/6 mice with medial meniscus surgery[1] Dosage: 10, 50 and 100 mg/kg Administration: Oral gavage; 10-100 mg/kg three times a week; for 6 weeks Result: Effectively protected osteoarthritis mice against cartilage destruction by catabolic factor expression.

[References]

[1]. Jeon J, et al. 3'-Sialyllactose protects against osteoarthritic development by facilitating cartilage homeostasis. J Cell Mol Med. 2018 Jan;22(1):57-66.

[2]. Kang LJ, et al. 3'-Sialyllactose prebiotics prevents skin inflammation via regulatory T cell differentiation in atopic dermatitis mouse models. Sci Rep. 2020 Mar 27;10(1):5603.

Chemical & Physical Properties

[ Density]:
1.72 g/cm3

[ Boiling Point ]:
1132.8ºC at 760 mmHg

[ Molecular Formula ]:
C₂₃H₃₉NO₁₉

[ Molecular Weight ]:
633.55100

[ Flash Point ]:
638.9ºC

[ Exact Mass ]:
633.21200

[ PSA ]:
342.92000

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
B

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Molecular Characterisation of the Haemagglutinin Glycan-Binding Specificity of Egg-Adapted Vaccine Strains of the Pandemic 2009 H1N1 Swine Influenza A Virus.

Molecules 20 , 10415-34, (2015)

The haemagglutinin (HA) glycan binding selectivity of H1N1 influenza viruses is an important determinant for the host range of the virus and egg-adaption during vaccine production. This study integrat...

Rapid screening and identification of active ingredients in licorice extract interacting with V3 loop region of HIV-1 gp120 using ACE and CE-MS.

J. Pharm. Biomed. Anal. 111 , 28-35, (2015)

The binding of envelope protein gp120 to glycosphingolipids is very important during the human immunodeficiency virus entering into the host cell. This step occurs in the V3 loop region in particularl...

Increased sialylation as a phenomenon in accommodation of the parasitic nematode Trichinella spiralis (Owen, 1835) in skeletal muscle fibres.

Folia Parasitol (Praha) 62 , (2015)

The biology of sialic acids has been an object of interest in many models of acquired and inherited skeletal muscle pathology. The present study focuses on the sialylation changes in mouse skeletal mu...