estren

[ Molecular Formula ]:
C₁₈H₂₈O₂

[ Molecular Weight ]:
276.41400

[ Exact Mass ]:
276.20900

[ PSA ]:
40.46000

[ LogP ]:
3.28090

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Click to get detail synthetic route

Precursor

DownStream

Reversal of bone loss in mice by nongenotropic signaling of sex steroids.

Science 298 , 843-846, (2002)

We show that sex steroids protect the adult murine skeleton through a mechanism that is distinct from that used to preserve the mass and function of reproductive organs. The classical genotropic actio...

The nongenotropic synthetic ligand 4-estren-3alpha17beta-diol is a high-affinity genotropic androgen receptor agonist.

Mol. Pharmacol. 67 , 744-748, (2005)

The nongenotropic ligand estren (Science 298:843-846, 2002) was evaluated for its transcriptional activity mediated by the human androgen receptor (AR). Our results show that estren can bind, transloc...

The synthetic estrogen 4-estren-3 alpha,17 beta-diol (estren) induces estrogen-like neuroprotection.

Neurobiol. Dis. 19 , 331-339, (2005)

Estrogen has demonstrated neuroprotective properties, which may underlie the observed preventive effect of estrogen-based hormone therapy (HT) against the development of neurodegenerative disorders su...

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