Methyl Vinyl sulphone
Names
[ CAS No. ]:
3680-02-2
[ Name ]:
Methyl Vinyl sulphone
[Synonym ]:
1-methylsulfonylethene
EINECS 222-958-0
MFCD00007567
Ethene, (methylsulfinyl)-
(Methylsulfinyl)ethene
Methyl vinyl sulfoxide
Sulfoxide, methyl vinyl
Methyl Vinyl sulphone
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
201.2±13.0 °C at 760 mmHg
[ Molecular Formula ]:
C3H6OS
[ Molecular Weight ]:
90.144
[ Flash Point ]:
75.5±19.8 °C
[ Exact Mass ]:
90.013931
[ PSA ]:
42.52000
[ LogP ]:
-0.73
[ Vapour Pressure ]:
0.4±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.505
[ Storage condition ]:
0-6°C
[ Stability ]:
Stable. Incompatible with strong oxidizing agents. Irritant.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- WR6825000
- CHEMICAL NAME :
- Sulfone, methyl vinyl
- CAS REGISTRY NUMBER :
- 3680-02-2
- BEILSTEIN REFERENCE NO. :
- 0878198
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C3-H6-O2-S
- MOLECULAR WEIGHT :
- 106.15
- WISWESSER LINE NOTATION :
- WS1&1U1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 570 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 32 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 1 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 245,191,1990
Safety Information
[ Symbol ]:
GHS05, GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H302-H310-H318
[ Precautionary Statements ]:
P280-P302 + P350-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T+:Verytoxic;
[ Risk Phrases ]:
R22;R27;R41
[ Safety Phrases ]:
S26-S28-S36/37/39-S45-S28A
[ RIDADR ]:
UN 2810 6.1/PG 1
[ WGK Germany ]:
3
[ RTECS ]:
WR6825000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1
[ HS Code ]:
2904100000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2904100000
[ Summary ]:
2904100000 derivatives containing only sulpho groups, their salts and ethyl esters。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
Articles
Oncotarget 5(14) , 5559-69, (2014)
Usp5 is a deubiquitinase (DUB) previously shown to regulate unanchored poly-ubiquitin (Ub) chains, p53 transcriptional activity and double-strand DNA repair. In BRAF mutant melanoma cells, Usp5 activi...
Protein reactions with methyl and ethyl vinyl sulfones.J. Protein Chem. 7(1) , 49-54, (1988)
Disulfide bonds of bovine serum albumin and wool were reduced by n-tributylphosphine to sulfhydryl groups that were then modified by methyl or ethyl vinyl sulfone in a nucleophilic addition reaction t...
Trypanocidal activities of trileucine methyl vinyl sulfone proteasome inhibitors.Parasitol. Res. 95(1) , 73-6, (2005)
Previous studies have shown that proteasome inhibitors are novel agents for chemotherapy of human African trypanosomiasis or sleeping sickness. In this study, five peptide trileucine methyl vinyl sulf...