1,3-Difluorobenzene

Names

[ CAS No. ]:
372-18-9

[ Name ]:
1,3-Difluorobenzene

[Synonym ]:
1,3-difluroethylene
1-Difluorobenzene
MFCD00000327
3-DifluoroBenzene
meta-difluorobenzene
m-Difluorobenzene
m-Difluro Benzene
1,3 difluorobenzene
1,3-DIFLUOROBENZEN
FR CF
2,4-difluorobenzene
m-difluoro-benzen
2,6-difluorobenzene
Benzene,m-difluoro
Benzene, 1,3-difluoro-
1,3-Difluorobenzene
DIFLOUROBENZENE
1,3-Difluorbenzol
EINECS 206-746-5

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
83.9±13.0 °C at 760 mmHg

[ Melting Point ]:
-59 °C

[ Molecular Formula ]:
C₆H₄F₂

[ Molecular Weight ]:
114.093

[ Flash Point ]:
2.2±0.0 °C

[ Exact Mass ]:
114.028107

[ LogP ]:
2.36

[ Vapour Pressure ]:
82.7±0.1 mmHg at 25°C

[ Index of Refraction ]:
1.449

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ5652000

CHEMICAL NAME :: Benzene, m-difluoro-

CAS REGISTRY NUMBER :: 372-18-9

LAST UPDATED :: 199501

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C6-H4-F2

MOLECULAR WEIGHT :: 114.10

WISWESSER LINE NOTATION :: FR CF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 55 gm/m3/2H

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS

REFERENCE :: IZSBAI Izvestiya Sibirskogo Otdeleniya Akademii Nauk SSSR, Seriya Biologomeditsinskikh Nauk. (Novosibirsk, USSR) No.1-3, 1963-68. For publisher information, see ISBNBN. Volume(issue)/page/year: 3,91,1965

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H332

[ Precautionary Statements ]:
P210

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F:Flammable

[ Risk Phrases ]:
R11;R20

[ Safety Phrases ]:
S7-S16-S29-S33

[ RIDADR ]:
UN 1993 3/PG 2

[ WGK Germany ]:
1

[ RTECS ]:
CZ5652000

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
29036990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Novel synthesis of desymmetrized resorcinol derivatives: aryl fluoride displacement on deactivated substrates.

J. Org. Chem. 71(5) , 2170-2, (2006)

A short, high-yielding synthesis of differentially substituted resorcinol derivatives has been developed that utilizes 1,3-difluorobenzene as the starting material and employs sequential nucleophilic ...

Decomposition of alpha-hydroxyaryl ketones and characterization of some unusual products.

J. Pharm. Sci. 81(12) , 1199-203, (1992)

Alpha-Hydroxyaryl ketones such as 2-hydroxypropiophenone and 1-(2,4-difluorophenyl)-2-hydroxy-1-propanone, the key intermediates in the preparation of antifungal agents, decompose into oxidized, rearr...