2-Picolylamine

Names

[ Name ]:
2-Picolylamine

[Synonym ]:
aminomethylpyridine
2-Methyl-3-pyridinamine
2-Pyridinemethanamine
MFCD00129044
3-Amino-2-picoline
3-Pyridinamine, 2-methyl-
1-(pyridin-2-yl)methanamine
2-Picolylamine
2-(Aminomethyl)pyridine
Pyridine, 2-(aminomethyl)-
EINECS 223-090-5
2-Methylpyridin-3-amin
1-(2-Pyridinyl)methanamine
2-(Aminomethyl)pyridine;2-picolylamine
Pyridine, 2- (aminomethyl)-
N-2-Pyridylmethylamine
2-picolinamine
pyridin-2-ylmethanamine
2-aminomethyl-pyridine
2-methylpyridin-3-amine
2-Aminomethylpyridine

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
203.0±0.0 °C at 760 mmHg

[ Melting Point ]:
20°C

[ Molecular Formula ]:
C₆H₈N₂

[ Molecular Weight ]:
108.141

[ Flash Point ]:
90.0±0.0 °C

[ Exact Mass ]:
108.068748

[ PSA ]:
24.92000

[ LogP ]:
-0.40

[ Vapour Pressure ]:
0.3±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.552

[ Water Solubility ]:
SOLUBLE

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US1840000

CHEMICAL NAME :: Pyridine, 2-aminomethyl-

CAS REGISTRY NUMBER :: 3731-51-9

BEILSTEIN REFERENCE NO. :: 0108054

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C6-H8-N2

MOLECULAR WEIGHT :: 108.16

WISWESSER LINE NOTATION :: T6NJ B1Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 340 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 26,345,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 562 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45-S25

[ RIDADR ]:
UN 2735 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
US1840000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
29333999

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.

Bioorg. Med. Chem. 16 , 3530-6, (2008)

The first activation study of the human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms associated to tumors, hCA IX and XII, with a small library of natural and non-natural amino acids as well as aroma...

Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.

Bioorg. Med. Chem. Lett. 16 , 3955-9, (2006)

The first activation study of isoform XIII of carbonic anhydrase (CA, EC 4.2.1.1) is reported. A series of amino acids and amines incorporating protonatable moieties of the primary/heterocyclic amine ...

Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.

Bioorg. Med. Chem. 15 , 5351-7, (2007)

The secretory isozyme of human carbonic anhydrase (hCA, EC 4.2.1.1), hCA VI, has been cloned, expressed, and purified in a bacterial expression system. The kinetic parameters for the CO(2) hydration r...