4-Methoxy-7H-pyrimido[4,5-b][1,4]thiazin-6-amine
Names
[ CAS No. ]:
37497-00-0
[ Name ]:
4-Methoxy-7H-pyrimido[4,5-b][1,4]thiazin-6-amine
[Synonym ]:
4-Methoxy-7H-pyrimido(4,5-b)(1,4)thiazin-6-amine
Thomizin-Base
4-Methoxy-6-aminopyrimido<4,5-b>-1,4-thiazin
4-Methoxy-6-aminopyrimido<4,5-b>(1,4)thiazine
7H-Pyrimido(4,5-b)(1,4)thiazine,6-amino-4-methoxy
6-Amino-4-methoxy-7H-pyrimido(4,5-b)(1,4)thiazine
4-methoxy-7H-pyrimido[4,5-b][1,4]thiazin-6-ylamine
Chemical & Physical Properties
[ Density]:
1.64g/cm3
[ Boiling Point ]:
456.8ºC at 760 mmHg
[ Molecular Formula ]:
C7H8N4OS
[ Molecular Weight ]:
196.23000
[ Flash Point ]:
230.1ºC
[ Exact Mass ]:
196.04200
[ PSA ]:
98.69000
[ LogP ]:
0.71550
[ Index of Refraction ]:
1.774
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UW7864000
- CHEMICAL NAME :
- 7H-Pyrimido(4,5-b)(1,4)thiazine, 6-amino-4-methoxy-
- CAS REGISTRY NUMBER :
- 37497-00-0
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C7-H8-N4-O-S
- MOLECULAR WEIGHT :
- 196.25
- WISWESSER LINE NOTATION :
- T66 BN DN GN JS IHJ EO1 HZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,1205,1977
Safety Information
[ HS Code ]:
2934999090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%