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Abieta-8,11,13-trien-18-ol

Names

[ CAS No. ]:
3772-55-2

[ Name ]:
Abieta-8,11,13-trien-18-ol

[Synonym ]:
1-Phenanthrenemethanol, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-
[(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanol
Dehydroabietinol
Abieta-8,11,13-trien-18-ol

Biological Activity

[Description]:

Dehydroabietinol is an abietane diterpenoid. Dehydroabietinol has kinase inhibition activity for spleen tyrosine kinase (SYK) with an IC50 value of 46.4 μM. Dehydroabietinol can be used for the research of immune-mediated disease[1].

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Syk
Research Areas >> Inflammation/Immunology

[In Vitro]

Dehydroabietinol 对脾酪氨酸激酶 SYK 具有激酶抑制活性，IC50 值为 46.4 μM[1]。

[References]

[1]. Jun-Bo Gao, et al. Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors. J Nat Prod. 2018 Apr 27;81(4):998-1006.  

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
389.4±11.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H30O

[ Molecular Weight ]:
286.452

[ Flash Point ]:
136.2±15.1 °C

[ Exact Mass ]:
286.229675

[ PSA ]:
20.23000

[ LogP ]:
6.35

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.527

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds