Fenoxypropazine

Names

[ Name ]:
Fenoxypropazine

[Synonym ]:
Phenoxypropazine
Fenoxipropazinum
Fenoxypropazinum
Fenoxypropazine
Fenoxipropazina

Biological Activity

[Description]:

Phenoxypropazine is a potent monoamine oxidase (MAO) inhibitor. Phenoxypropazine can be used in research of depression[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Neurological Disease

[In Vivo]

Phenoxypropazine (32 mg/kg; i.h.) has sedation effect in LAC grey mice[1]. Animal Model: LAC grey mice (5-6 weeks age)[1] Dosage: 32 mg/kg Administration: Subcutaneous injection; once Result: Had sedation effect in LAC grey mice.

[References]

[1]. Davis RA, et, al. Effects of reserpine pre-treatment on the protective action of amphetamine and phenoxypropazine in the phenylbenzoquinone-induced writhing syndrome in mice. Nature. 1964 Jan 18;201:306-7.

Chemical & Physical Properties

[ Density]:
1.043g/cm3

[ Boiling Point ]:
312.7ºC at 760mmHg

[ Molecular Formula ]:
C₉H₁₄N₂O

[ Molecular Weight ]:
166.22000

[ Flash Point ]:
142.9ºC

[ Exact Mass ]:
166.11100

[ PSA ]:
47.28000

[ LogP ]:
2.00840

[ Index of Refraction ]:
1.53

Safety Information

[ RIDADR ]:
UN 3249

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2928000090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2928000090

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%