2,6-Difluorobenzoic acid

Names

[ CAS No. ]:
385-00-2

[ Name ]:
2,6-Difluorobenzoic acid

[Synonym ]:
QVR BF FF
2,6-difluoro-benzoic acid
Benzoic acid,2,6-difluoro
EINECS 206-856-3
2,6-difluorophenylcarboxylic acid
2,6-Difluor-benzoesaeure
2,6-Difluorobenzoicacid
2,6-Difluorobenzoic acid
MFCD00002411
Benzoic acid, 2,6-difluoro-
2,6-Difluoro benzoic acid

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
231.0±20.0 °C at 760 mmHg

[ Melting Point ]:
157-161 °C(lit.)

[ Molecular Formula ]:
C₇H₄F₂O₂

[ Molecular Weight ]:
158.102

[ Flash Point ]:
93.5±21.8 °C

[ Exact Mass ]:
158.017929

[ PSA ]:
37.30000

[ LogP ]:
1.86

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.513

[ Storage condition ]:
0-6°C

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG8559000

CHEMICAL NAME :: Benzoic acid, 2,6-difluoro-

CAS REGISTRY NUMBER :: 385-00-2

BEILSTEIN REFERENCE NO. :: 0973774

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H4-F2-O2

MOLECULAR WEIGHT :: 158.11

WISWESSER LINE NOTATION :: QVR BF FF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1 mg/plate

REFERENCE :: PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year: 10,174,1979

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DG8559000

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Synthesis of 2,6-difluoro-N-(3-[11C]methoxy-1H-pyrazolo[3,4-b]pyridine-5-yl)-3-(propylsulfonamidio)benzamide as a new potential PET agent for imaging of B-Raf(V600E) in cancers.

Bioorg. Med. Chem. Lett. 23(4) , 1017-21, (2013)

The authentic standard 2,6-difluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridine-5-yl)-3-(propylsulfonamidio)benzamide was synthesized from 2,6-difluorobenzoic acid and 3-amino-5-hydroxypyrazole in 9 steps...

Effect of diflubenzuron and its major degradation products on the growth of Euglena gracilis Z. and incorporation of glycine-U-14C in protein.

J. Environ. Sci. Health B 16(2) , 159-66, (1981)

Diflubenzuron (I) and its major degradation products 4-chlorophenyl urea (II), 2,6-difluorobenzoic acid (III) and 4-chloroaniline (IV) were tested for their activity on Euglena gracilis Z. The inhibit...

Synthesis and insecticidal evaluation of propesticides of benzoylphenylureas.

J. Agric. Food Chem. 53(1) , 38-41, (2005)

Two series of benzoylphenylurea derivatives were synthesized as candidate propesticides by a nucleophilic addition reaction between 2,6-difluronbenzoyl isocyanate and N-substitutedaniline. The new com...