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8-hydroxyguanosine

Names

[ CAS No. ]:
3868-31-3

[ Name ]:
8-hydroxyguanosine

[Synonym ]:
8-Hydroxy Guanosine
8-OXO-G
8-OXOGUANOSINE
8-Oxyguanosin
7,8-dihydro-8-oxo-Guanosine
7,8-Dihydroguanosine, 8-oxo-
7,8-dihydro-8-oxo-guanosin
8-OHG
8-oxo-7,8-dihydro-guanosine
8-OH-GUO
8-Hydroxy-guanosin
8-Oxo-7,8-dihydroguanosine
8-Oxo-D-guanosine
8-Oxoguanosin

Biological Activity

[Description]:

8-Hydroxyguanosine is a systematic marker of oxidative stress and a marker of hydroxyl radical damage to RNA.

[Related Catalog]:

Research Areas >> Metabolic Disease
Research Areas >> Neurological Disease
Natural Products >> Others

[Target]

Human Endogenous Metabolite


[References]

[1]. Fiala ES, et al. Oxidative DNA and RNA damage in the livers of Sprague-Dawley rats treated with the hepatocarcinogen 2-nitropropane. Cancer Res. 1989 Oct 15;49(20):5518-22.

[2]. Abe T, et al. Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease. J Neurosci Res. 2002 Nov 1;70(3):447-50.


[Related Small Molecules]

3-Methyladenine | Hydrocortisone | Acetylcysteine(N-acetylcysteine) | Retinoic acid | Melatonine | Dinoprostone | Nicotinamide | Adenosine triphosphate | 4-Acetamidophenol | Prostaglandin E1 | Dehydroepiandrosterone | Corticosterone | Progesterone | Docosahexaenoic Acid | NAD+

Chemical & Physical Properties

[ Density]:
2.4±0.1 g/cm3

[ Melting Point ]:
232-235ºC

[ Molecular Formula ]:
C10H13N5O6

[ Molecular Weight ]:
299.240

[ Exact Mass ]:
299.086578

[ PSA ]:
179.74000

[ LogP ]:
-0.97

[ Index of Refraction ]:
2.007

[ Storage condition ]:
-20°C Freezer

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds