ST-148
Names
[ CAS No. ]:
400863-77-6
[ Name ]:
ST-148
Biological Activity
[Description]:
ST-148 a novel potent, broad-spetrum inhibitor of dengue virus (DENV) replication, inhibits DENV-2 wth EC50 of 16 nM in viral titer reduction assays, interacts with the DENV Capsid protein; exhibits a broad range of potencies with EC50 of 0.512, 1.150, and 2.832 uM for DENV-3, -4, and -1, respectively; significantly reduced viremia and viral load in vital organs and tended to lower cytokine levels in the plasma in a nonlethal model of DENV infection in AG129 mice.
[References]
References 1. Byrd CM, et al. Antimicrob Agents Chemother. 2013 Jan;57(1):15-25. 2. Scaturro P, et al. J Virol. 2014 Oct;88(19):11540-55. View Related Products by Target Filovirus
Chemical & Physical Properties
[ Molecular Formula ]:
C21H19N5OS2
[ Molecular Weight ]:
421.537