5-Fluoronicotinic acid

Names

[ CAS No. ]:
402-66-4

[ Name ]:
5-Fluoronicotinic acid

[Synonym ]:
MFCD01318537
Nicotinic acid, 5-fluoro-
T6NJ CVQ EF
5-Fluoronicotinic acid
5-Fluoropyridine-3-carboxylic acid
5-Fluoro-3-pyridinecarboxylic acid
3-Pyridinecarboxylic acid, 5-fluoro-

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
272.2±20.0 °C at 760 mmHg

[ Melting Point ]:
199 °C

[ Molecular Formula ]:
C₆H₄FNO₂

[ Molecular Weight ]:
141.100

[ Flash Point ]:
118.4±21.8 °C

[ Exact Mass ]:
141.022614

[ PSA ]:
50.19000

[ LogP ]:
0.41

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.542

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US5745250

CHEMICAL NAME :: 3-Pyridinecarboxylic acid, 5-fluoro-

CAS REGISTRY NUMBER :: 402-66-4

LAST UPDATED :: 199806

DATA ITEMS CITED :: 1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3737542

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
US5745250

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Pyridonecarboxylic acids as antibacterial agents. VIII. An alternative synthesis of enoxacin via fluoronicotinic acid derivatives.

Chem. Pharm. Bull. 35(6) , 2280-5, (1987)

Hydrophobic chromatography and bioanalysis of some polar pyridine derivatives used as antilipolytic agents.

J. Chromatogr. A. 187(1) , 189-98, (1980)

The antilipolytic compound 5-fluoro-3-pyridinecarboxylic acid and 5-fluoro-3-hydroxymethylpyridine have been determined quantitatively in plasma (Srel = 5-7% in the concentration range 1-20 microgram/...