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[3-acetyloxy-14-hydroxy-10,13-dimethyl-17-(6-oxopyran-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-16-yl] acetate

Names

[ CAS No. ]:
4029-69-0

[ Name ]:
[3-acetyloxy-14-hydroxy-10,13-dimethyl-17-(6-oxopyran-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-16-yl] acetate

[Synonym ]:
digitoxigenin3-rhamnoside
evomonosid
a-hydroxy
3-O-acetylbufotalin
digitoxigenin rhamnoside
DIGITOXIGENIN-3-O-A-L-RHAMNOPYRANOSIDE
DIGITOXIGENIN-3-O-RHAMNOSIDE
Digitoxigenine-3-rhamnoside

Biological Activity

[Description]:

3-O-Acetylbufotalin is a derivate of bufadienolide, with anti-cancer activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

3-O-Acetylbufotalin (2b) inhibits the growth of six human cancer cell lines, with a mean IC50 of 159 nM[1].

[References]

[1]. Moreno Y Banuls L, et al. Structure-activity relationship analysis of bufadienolide-induced in vitro growth inhibitory effects on mouse and human cancer cells.

Chemical & Physical Properties

[ Density]:
1.24g/cm3

[ Boiling Point ]:
596.6ºC at 760 mmHg

[ Molecular Formula ]:
C28H38O7

[ Molecular Weight ]:
486.59700

[ Flash Point ]:
191.9ºC

[ Exact Mass ]:
486.26200

[ PSA ]:
103.04000

[ LogP ]:
4.35430

[ Vapour Pressure ]:
1.02E-16mmHg at 25°C

[ Index of Refraction ]:
1.57

Related Compounds