(±)-trans-Nerolidol

Names

[ Name ]:
(±)-trans-Nerolidol

[Synonym ]:
EINECS 255-053-4
±-trans-Nerolidol
1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-, (6E)-
Nerolidol, E-
(6E)-3,7,11-Trimethyl-1,6,10-dodecatrien-3-ol
Nerolidol trans-form
Peruviol
(6E)-Nerolidol
10,11-Dihydronerolidol
(E)-3,7,11-Trimethyl-1,6,10-dodecatrien-3-ol,trans-3,7,11-Trimethyl-1,6,10-dodecatrien-3-ol
Nerolidol, trans
trans-1-Cyclohexyl-2,3-dibenzoyl-aziridin
MFCD00008911
Nerolidol
(±)-trans-Nerolidol
6,7-dihydronerolidol
E-Nerolidol
(±)-Nerolidol
3,7,11-trimethyldodeca-1,6,10-trien-3-ol
(6E)-3,7,11-trimethyldodeca-1,6,10-trien-3-ol
1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-, (E)-
Trans-nerolidol
trans-N-Cyclohexyl-2,3-dibenzoyl-aziridin

Biological Activity

[Description]:

trans-Nerolidol is a sesquiterpene alcohol. It can be isolated from f aerial parts of Warionia saharae ex Benth. trans-Nerolidol improves the anti-proliferative effect of Doxorubicin (HY-15142A) against intestinal cancer cells in vitro. trans-Nerolidol also has anti-fungal activity[1][2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[References]

[1]. Hanušová V, et al. The effects of β-caryophyllene oxide and trans-nerolidol on the efficacy of doxorubicin in breast cancer cells and breast tumor-bearing mice. Biomed Pharmacother. 2017 Nov;95:828-836.

[2]. Chan WK, et al. Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities. Molecules. 2016 Apr 28;21(5):529.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
276.0±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₂₆O

[ Molecular Weight ]:
222.366

[ Flash Point ]:
96.1±0.0 °C

[ Exact Mass ]:
222.198364

[ PSA ]:
20.23000

[ LogP ]:
5.32

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.480

[ Storage condition ]:
?20°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ HS Code ]:
2905290000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2905290000

[ Summary ]:
2905290000 unsaturated monohydric alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

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