2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-2,4,12,16,18,20,22-heptamethyl-23-methoxy-8-(morpholinomethyl)-, 21-acetate

Names

[ Name ]:
2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-2,4,12,16,18,20,22-heptamethyl-23-methoxy-8-(morpholinomethyl)-, 21-acetate

[Synonym ]:
PF-49
NCI 144-143
2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2H)-dione,5,6,9,17,19,21-hexahydroxy-2,4,12,16,18,20,22-heptamethyl-23-methoxy-8-(morpholinomethyl)-,21-acetate

Chemical & Physical Properties

[ Density]:
1.35g/cm3

[ Boiling Point ]:
907.6ºC at 760 mmHg

[ Molecular Formula ]:
C₄₂H₅₆N₂O₁₃

[ Molecular Weight ]:
796.90000

[ Flash Point ]:
502.7ºC

[ Exact Mass ]:
796.37800

[ PSA ]:
213.78000

[ LogP ]:
4.66220

[ Index of Refraction ]:
1.634

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KD1920700

CHEMICAL NAME :: 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b) furan-1,11(2H)-dione, 5,6,9,17,19,21- hexahydroxy-2,4,12,16,18,20,22-heptamethyl-23-methoxy -8-(morpholinomethyl) -, 21-acetate

CAS REGISTRY NUMBER :: 4075-43-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C42-H56-N2-O13

MOLECULAR WEIGHT :: 797.00

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 188 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38KLAC "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977 Volume(issue)/page/year: -,531,1977