2-(1-Adamantyl)-4-methylphenol

Names

[ Name ]:
2-(1-Adamantyl)-4-methylphenol

[Synonym ]:
2-(1-adamantyl)-4-methyl-1-hydroxybenzene
2-(Adamantan-1-yl)-4-methylphenol
2-Adamantan-1-yl-4-methyl-phenol
2,6-DIBROMO-4-METHYLANILINE
2-(adamantyl)-p-cresol
2-adamantyl-4-methylphenol
MFCD00168147
2-(1-adamantyl)-p-cresol
2-admantyl-4-methylphenol
Phenol, 4-methyl-2-tricyclo[3.3.1.1]dec-1-yl-
Phenol, 4-methyl-2-tricyclo[3.3.1.1(3,7)]dec-1-yl-

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
359.9±21.0 °C at 760 mmHg

[ Melting Point ]:
128-130ºC(lit.)

[ Molecular Formula ]:
C₁₇H₂₂O

[ Molecular Weight ]:
242.356

[ Flash Point ]:
169.5±10.6 °C

[ Exact Mass ]:
242.167068

[ PSA ]:
20.23000

[ LogP ]:
5.28

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.604

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2907199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2907199090

[ Summary ]:
2907199090 other monophenols VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Ion-exchange-resin-catalyzed adamantylation of phenol derivatives with adamantanols: Developing a clean process for synthesis of 2-(1-adamantyl)-4-bromophenol, a key intermediate of adapalene.

Beilstein J. Org. Chem. 8 , 227-33, (2012)

A clean process has been developed for the synthesis of 2-adamantylphenol derivatives through adamantylation of substituted phenols with adamantanols catalyzed by commercially available and recyclable...

Synthesis of 2, 4-disubstituted thiophenols and solid state structures of thiocarbamate precursors. Flores-Figueroa A, et al

J. Braz. Chem. Soc. 16.3A , 397-403, (2005)

Reactions of 2-hydroxymethylphenols with Lawesson's reagent. Osyanin VA, et al

Chem. Heterocycl. Comp. 47(7) , 901-905, (2011)