DICHLOROACETIC ANHYDRIDE

Names

[ CAS No. ]:
4124-30-5

[ Name ]:
DICHLOROACETIC ANHYDRIDE

[Synonym ]:
(2,2-dichloroacetyl) 2,2-dichloroacetate
EINECS 223-924-8
MFCD00000842
Dichloroacetic anhydride

Chemical & Physical Properties

[ Density]:
1.695g/cm3

[ Boiling Point ]:
215ºC at 760mmHg

[ Melting Point ]:
-30ºC

[ Molecular Formula ]:
C₄H₂Cl₄O₃

[ Molecular Weight ]:
239.86900

[ Flash Point ]:
90.6ºC

[ Exact Mass ]:
237.87600

[ PSA ]:
43.37000

[ LogP ]:
1.66360

[ Appearance of Characters ]:
Liquid After Melting | Clear colorless

[ Index of Refraction ]:
n20/D 1.483(lit.)

[ Storage condition ]:
Store below +30°C.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AG6300000

CHEMICAL NAME :: Acetic acid, dichloro-, anhydride

CAS REGISTRY NUMBER :: 4124-30-5

BEILSTEIN REFERENCE NO. :: 0512173

LAST UPDATED :: 199806

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C4-H2-Cl4-O3

MOLECULAR WEIGHT :: 239.86

WISWESSER LINE NOTATION :: GYGVOVYGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,574,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2820 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 470 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H311-H314-H332

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C

[ Risk Phrases ]:
R21;R34

[ Safety Phrases ]:
S26;S27;S28;S45;S36/S37/S39

[ RIDADR ]:
UN 2923 8/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
AG6300000

[ Packaging Group ]:
II

[ HS Code ]:
2915900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2915900090

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

Articles

Autoimmune response in MRL+/+ mice following treatment with dichloroacetyl chloride or dichloroacetic anhydride.

Toxicol. Appl. Pharmacol. 216(2) , 248-55, (2006)

Dichloroacetyl chloride (DCAC) is formed from trichloroethene (TCE), which is implicated in inducing/accelerating autoimmune response. Due to its potent acylating activity, DCAC may convert proteins t...

Selective enzymatic acylation of 10-deacetylbaccatin III. Lee D, et al.

Tetrahedron Lett. 39(49) , 9039-42, (1998)

A new soluble and hydrolytically cleavable intermediate in cellulose functionalization: cellulose dichloroacetate (CDCA). Liebert T and Klemm D.

Acta Polym. 49(2-3) , 124-28, (1998)