GS-389

Names

[ Name ]:
GS-389

[Synonym ]:
coclaurine dimethyl ether
1,2,3,4-tetrahydro-6,7-dimethoxy-1-[(4-methoxyphenyl)methyl]isoquinoline
7,12-O,O'-dimethylcoclaurine
N-(3,4-dimethoxyphenylethyl)-2-(3-methoxyphenyl)acetamide
6,7-dimethoxy-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydroisoquinoline
rac-O,O-dimethylcoclaurine
GS-389
(+/-)-1-(4-methoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Biological Activity

[Description]:

GS 389 ((±)-O,O-Dimethylcoclaurine) is a tetrahydroisoquinoline. GS-389 inhibites Cyclic AMP and cyclic AMP dependent phosphodiesterases from rat atrial and ventricular tissue. GS-389 relaxes the contraction induced by phenylephrine and high K+ in rat aortic rings[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. Chang KC, et al. Different pharmacological characteristics of structurally similar benzylisoquinoline analogs, papaverine, higenamine, and GS 389, on isolated rat aorta and heart. Can J Physiol Pharmacol. 1994;72(4):327-334.

Chemical & Physical Properties

[ Density]:
1.108g/cm3

[ Boiling Point ]:
454ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₃NO₃

[ Molecular Weight ]:
313.39100

[ Flash Point ]:
191.6ºC

[ Exact Mass ]:
313.16800

[ PSA ]:
39.72000

[ LogP ]:
3.47070

[ Index of Refraction ]:
1.557

Safety Information

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%