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nitrocefin

Names

[ CAS No. ]:
41906-86-9

[ Name ]:
nitrocefin

[Synonym ]:
(6R-(3(E),6a,7b))-3-(2-(2,4-Dinitrophenyl)ethenyl)-8-oxo-7-((2-thienylacetyl)amino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(E)-2-(2,4-dinitrophenyl)ethenyl]-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-, (6R,7R)-
nitrocefin
(6R,7R)-3-[(E)-2-(2,4-Dinitrophenyl)vinyl]-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Biological Activity

[Description]:

Nitrocefin is a chromogenic β-lactamase substrate that undergoes distinctive color change from yellow to red as the amide bond in the β-lactam ring is hydrolyzed by β-lactamase. Nitrocefin is used in competitive inhibition studies in developmental work on β-lactamase-resistant antibiotics[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Shannon K, Phillips I. beta-Lactamase detection by three simple methods: Intralactam, nitrocefin and acidimetric. J Antimicrob Chemother. 1980 Sep;6(5):617-21.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
872.0±65.0 °C at 760 mmHg

[ Melting Point ]:
>99℃

[ Molecular Formula ]:
C21H16N4O8S2

[ Molecular Weight ]:
516.504

[ Flash Point ]:
481.2±34.3 °C

[ Exact Mass ]:
516.040955

[ PSA ]:
231.89000

[ LogP ]:
1.04

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.749

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds