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1,1,1-Trifluoroacetone

Names

[ CAS No. ]:
421-50-1

[ Name ]:
1,1,1-Trifluoroacetone

[Synonym ]:
1,1,1-Trifluorpropan-2-on
EINECS 207-005-9
1,1,1-Trifluoroacetone
2-Propanone, 1,1,1-trifluoro-
MFCD00000423
1,1,1-trifluoropropan-2-one

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
21.5±0.0 °C at 760 mmHg

[ Melting Point ]:
-78 °C

[ Molecular Formula ]:
C3H3F3O

[ Molecular Weight ]:
112.050

[ Flash Point ]:
-30.6±0.0 °C

[ Exact Mass ]:
112.013596

[ PSA ]:
17.07000

[ LogP ]:
0.49

[ Vapour Pressure ]:
865.9±0.0 mmHg at 25°C

[ Index of Refraction ]:
1.287

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
Miscible

MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H224-H315-H319-H335

[ Precautionary Statements ]:
P210-P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)

[ Hazard Codes ]:
F+:Highlyflammable;Xi:Irritant;

[ Risk Phrases ]:
R12;R36/37/38

[ Safety Phrases ]:
S16-S26-S29-S33-S36-S7/9-S9-S37/39

[ RIDADR ]:
UN 1993 3/PG 1

[ WGK Germany ]:
3

[ Packaging Group ]:
I

[ Hazard Class ]:
3

[ HS Code ]:
29147090

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Articles

Mitochondrial dysfunction and respiratory chain defects in a rodent model of methotrexate-induced enteritis.

Hum. Exp. Toxicol. 33(10) , 1051-65, (2014)

The efficacy of methotrexate (MTX), a widely used chemotherapeutic drug, is limited by its gastrointestinal toxicity and the mechanism of which is not clear. The present study investigates the possibl...

Concise synthesis of enantiopure alpha-trifluoromethyl alanines, diamines, and amino alcohols via the Strecker-type reaction.

J. Org. Chem. 71 , 7075, (2006)

Diastereomerically pure alpha-trifluoromethyl alpha-amino nitriles obtained by Strecker-type reactions from chiral CF3 imines and iminium proved to be very attractive versatile intermediates for the s...

Synthesis , 251, (2007)


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