Disodium 2'-deoxy-5'-O-phosphonatouridine

Names

[ Name ]:
Disodium 2'-deoxy-5'-O-phosphonatouridine

[Synonym ]:
5'-Uridylic acid, 2'-deoxy-, sodium salt (1:2)
2'-Deoxyuridine 5'-monophosphate disodium salt
EINECS 255-687-1
Disodium 2'-deoxy-5'-O-phosphonatouridine
MFCD00065282
2'-Deoxyuridine 5'-mono-phos-phate disodium salt

Biological Activity

[Description]:

2'-Deoxyuridine 5'-monophosphate disodium is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. Zachary Newby, et al. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry. 2006 Jun 20;45(24):7415-28.

Chemical & Physical Properties

[ Density]:
1.742 g/cm3

[ Molecular Formula ]:
C₉H₁₁N₂Na₂O₈P

[ Molecular Weight ]:
352.146

[ Exact Mass ]:
352.004852

[ PSA ]:
166.55000

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn,Xi

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
26-36-37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Simultaneous quantification of 5-FU, 5-FUrd, 5-FdUrd, 5-FdUMP, dUMP and TMP in cultured cell models by LC-MS/MS

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877 , 2937-2944, (2009)

To specifically quantify several metabolites of 5-fluorouracil (5-FU) and two endogenous monophosphate nucleotides, we developed an original method based on a liquid chromatography–tandem mass spectro...

Ultrafast real-time visualization of active site flexibility of flavoenzyme thymidylate synthase ThyX.

Proc. Natl. Acad. Sci. U. S. A. 110(22) , 8924-9, (2013)

In many bacteria the flavoenzyme thymidylate synthase ThyX produces the DNA nucleotide deoxythymidine monophosphate from dUMP, using methylenetetrahydrofolate as carbon donor and NADPH as hydride dono...

Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase.

J. Neurosci. 28 , 7219-7230, (2008)

Folate deficiency and resultant increased homocysteine levels have been linked experimentally and epidemiologically with neurodegenerative conditions like stroke and dementia. Moreover, folate deficie...