TKDC

Names

[ Name ]:
TKDC

[Synonym ]:
Methanesulfonamide, N-(4-chlorophenyl)-N-[2-(3,4-dihydro-2(1H)-isoquinolinyl)-2-oxoethyl]-
N-(4-chlorophenyl)-N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]methanesulfonamide
N-(4-Chlorophenyl)-N-[2-(3,4-dihydro-2(1H)-isoquinolinyl)-2-oxoethyl]methanesulfonamide

Biological Activity

[Description]:

TKDC is a small molecule allosteric inhibitor of TREK channels with IC50 of 4.9, 5.2 and 65.9 uM for TREK-1, TREK-2 and TRAAK, respectively; maintains potency for mutant TREK-1 channels with IC50 of 2.4, 2.4 and 2.2 uM for T79A TREK-1, Q83A TREK-1 and Q105A TREK-1, respectively; decreases immobility and induces antidepressant-like effects in mice.

[References]

References 1. Luo Q, et al. Nat Commun. 2017 Aug 29;8(1):378. View Related Products by Target Potassium Channel

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
588.2±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₉ClN₂O₃S

[ Molecular Weight ]:
378.873

[ Flash Point ]:
309.5±32.9 °C

[ Exact Mass ]:
378.080475

[ LogP ]:
3.45

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.640