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7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydropyrido[3,2-e][1,4]diazepin-2-one

Names

[ CAS No. ]:
42863-81-0

[ Name ]:
7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydropyrido[3,2-e][1,4]diazepin-2-one

[Synonym ]:
Lopirazepam [INN]
2H-Pyrido(3,2-e)-1,4-diazepin-2-one,1,3-dihydro-7-chloro-5-(2-chlorophenyl)-3-hydroxy
3-Hydroxy-5-o-chlorophenyl-6-aza-7-chloro-1,2-dihydro-3H-1,4-benzodiazepinone
EINECS 255-974-1
Lopirazepamum [INN-Latin]
2H-Pyrido(3,2-e)-1,4-diazepin-2-one,7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy
7-chloro-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-pyrido[3,2-e][1,4]diazepin-2-one
7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2h-pyrido[3,2-e][1,4]diazepin-2-one
7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-pyrido(3,2-e)-1,4-diazepin-2-one
Lopirazepam

Biological Activity

[Description]:

Lopirazepam is a potent small molecule GABAA receptor agonist, which can be used to treat anxiety disorders, insomnia, epilepsy and other diseases.

[References]

1. Fabian A,et al. Veränderungen der Dauer der Schlafzyklen unter Flurazepam und Lopirazepam [Changes in the length of sleep cycles during administration of flurazepam and lopirazepam]. EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb. 1984 Sep;15(3):151-8. German.

Chemical & Physical Properties

[ Density]:
1.61g/cm3

[ Boiling Point ]:
563.9ºC at 760mmHg

[ Molecular Formula ]:
C14H9Cl2N3O2

[ Molecular Weight ]:
322.14600

[ Flash Point ]:
294.8ºC

[ Exact Mass ]:
321.00700

[ PSA ]:
78.07000

[ LogP ]:
2.01700

[ Index of Refraction ]:
1.726

Related Compounds