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MMRi64

Names

[ CAS No. ]:
430458-66-5

[ Name ]:
MMRi64

Biological Activity

[Description]:

MMRi64 is a small molecule inhibitor that disrupts Mdm2-MdmX RING-RING interaction interactions in vitro and activates p53 in cancer cells; potently induces downregulation of Mdm2 and MdmX in leukemia cells, only induces the expression of pro-apoptotic gene PUMA (p53 upregulated modulator of apoptosis) with minimal induction of growth-arresting gene p21; selectively induces the apoptotic arm of the p53 pathway in leukemia/lymphoma cells; synergistically induces p53 and apoptosis in combination with Nutlin3a.

[References]

References 1. Wu W, et al. Cell Death Dis. 2015 Dec 31;6:e2035. View Related Products by Target MDM2-p53

Chemical & Physical Properties

[ Molecular Formula ]:
C22H17Cl2N3O

[ Molecular Weight ]:
410.298


Related Compounds