Z-590

Z-590 is a potent inhibitor of macrophage migration inhibitory factor (MIF) tautomerase activity; significantly decreases the production of nitric oxide (NO), TNF-α, interleukin (IL)-6, IL-1β, cyclooxygenase (COX-2), inducible nitric oxide synthase (iNOS) as well as reactive oxygen species (ROS) involved in inhibiting MAKPs signalling pathway in LPS-stimulated microglia cells; suppresses cartilage destruction in adjuvant-induced arthritis via inhibition of macrophage inflammatory activatio in vivo.

References 1. Zhang Z, et al. Immunopharmacol Immunotoxicol. 2018 Apr;40(2):149-157. 2. Zhang Y, et al. Clin Exp Pharmacol Physiol. 2016 Nov;43(11):1134-1144. View Related Products by Target Other Targets