VU 0357121

Names

[ Name ]:
VU 0357121

[Synonym ]:
Benzamide, 4-butoxy-N-(2,4-difluorophenyl)-
4-Butoxy-N-(2,4-difluorophenyl)benzamide
4-Butoxy-N-(2,4-difluorophenyl)-benzamide
VU 0357121
cc-377
VU-0357121
VU0357121

Biological Activity

[Description]:

VU0357121 is a novel positive and highly selective allosteric modulator (PAM) of mGlu5R with EC50 of 33 nM.IC50 Value: 33 nM(EC50)Target: mGluR5in vitro: VU0357121 do not bind at the MPEP allosteric site of mGlu5, thus do not possess mGlu5 NAM activity. The A809V/rmGlu5 mutation inhibited the ability of VU0357121 to shift the glutamate concentration?response curve, whereas the response to VU0357121 is not altered by the F585I/rmGlu5 mutation. VU0357121 show weaker cooperativity in the Ca2+ mobilization assay in the low-expressing HEK293A-mGlu5 cell line. in vivo:

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Hammond, Alexis S.; Rodriguez, Alice L.; Townsend, Steven D. et al. Discovery of a Novel Chemical Class of mGlu5 Allosteric Ligands with Distinct Modes of Pharmacology. ACS Chemical Neuroscience (2010), 1(10), 702-716.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
338.7±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₇F₂NO₂

[ Molecular Weight ]:
305.319

[ Flash Point ]:
158.7±27.9 °C

[ Exact Mass ]:
305.122742

[ PSA ]:
38.33000

[ LogP ]:
4.78

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.564

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: ≥18mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H410

[ Precautionary Statements ]:
P273-P501

[ Hazard Codes ]:
N

[ Risk Phrases ]:
50/53

[ Safety Phrases ]:
60-61

[ RIDADR ]:
UN 3077 9 / PGIII