Monomethyl phthalate

Names

[ Name ]:
Monomethyl phthalate

[Synonym ]:
1,2-Benzenedicarboxylic acid, monomethyl ester
Phthalic acid methyl ester
2-methoxycarbonylbenzoic acid
2-(Methoxycarbonyl)benzoic acid
Monomethyl phthalate
METHYL HYDROGEN PHTHALATE
phthalic acid, mono-methyl ester
MFCD00002466
1,2-Benzenedicarboxylic acid monomethyl ester
EINECS 224-476-6
Phthalic acid monomethyl ester
mono-Methyl phthalate

Biological Activity

[Description]:

Monomethyl phthalate is a phthalate metabolite. Monomethyl phthalate acts as a urinary biomarker of phthalates exposure and can be used as a standard for the determination of thyroid cancer and benign nodule[1].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Chong Liu, et al. Urinary biomarkers of phthalates exposure and risks of thyroid cancer and benign nodule. J Hazard Mater. 2020 Feb 5;383:121189.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
328.9±25.0 °C at 760 mmHg

[ Melting Point ]:
82-84 °C(lit.)

[ Molecular Formula ]:
C₉H₈O₄

[ Molecular Weight ]:
180.157

[ Flash Point ]:
134.7±16.7 °C

[ Exact Mass ]:
180.042252

[ PSA ]:
63.60000

[ LogP ]:
1.13

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.556

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Feasibility of ultra-high performance liquid and gas chromatography coupled to mass spectrometry for accurate determination of primary and secondary phthalate metabolites in urine samples.

Anal. Chim. Acta 853 , 625-36, (2014)

Phthalates (PAEs) are ubiquitous toxic chemical compounds. During the last few years, some phthalate metabolites (MPAEs) have been proposed as appropriate biomarkers in human urine samples to determin...

Monitoring of PAEMs and beta-agonists in urine for a small group of experimental subjects and PAEs and beta-agonists in drinking water consumed by the same subjects.

J. Hazard. Mater. 277 , 169-79, (2014)

This 5-month study contains two parts: (1) to monitor the concentrations of 11 phthalate esters metabolites (PAEMs) and two beta-agonists in human urine samples collected from a small group of consent...

Phthalate Metabolites in Urine Samples from School Children in Taipei, Taiwan.

Arch. Environ. Contam. Toxicol. 69 , 202-7, (2015)

In 2011, Taiwan authorities reported that two phthalates, including di-(2-ethylhexyl) phthalate and di-iso-nonyl phthalate, were intentionally introduced into a variety of foods and beverages during t...